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Skin reactions, allergic reactions, and changes in blood tests of liver function have also been reported in the early breast cancer clinical trial, the most common side effects seen with arimidex include hot flashes, joint symptoms including arthritis and arthralgia , weakness, mood changes, pain, back pain, sore throat, nausea and vomiting, rash, depression, high blood pressure, osteoporosis, fractures, swelling of arms legs, insomnia, and headache in advanced breast cancer trials, the most common side effects seen with arimidex versus tamoxifen include hot flashes, nausea, decreased energy and weakness, pain, back pain, headache, bone pain, increased cough, shortness of breath, sore throat, and swelling of arms and legs.

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